Pleiotropic, heart rate-independent cardioprotection by ivabradine
نویسندگان
چکیده
منابع مشابه
Ivabradine: heart rate and left ventricular function.
intravenous administration of ivabradine caused no serious adverse events, with only four mild adverse events possibly related to ivabradine, all of which resolved spontaneously on the same day. Thus, Manz et al. [1] demonstrated that ivabradine is not just another reducer of heart rate. It is the only compound that can reduce heart rate without affecting any other hemodynamic parameter and wit...
متن کاملModulation of sympathetic activity and heart rate variability by ivabradine.
AIMS Bradycardic agents are currently used in the treatment of angina and heart failure; direct information on their effects on cardiac sympathetic nerve activity (SNA) may be relevant to their chronic use. The present study evaluates the effect of pacemaker inhibition on SNA; direct nerve recordings and indirect autonomic indexes are compared. METHODS AND RESULTS Experiments were performed i...
متن کاملAdenosine receptors, heart rate, and cardioprotection.
See article by Fabritz et al. [1] (pages 500-508) in this issue. In this issue of Cardiovascular Research, a paper by Fabritz et al. [1] investigates the effects of controlled overexpression of the A3 adenosine receptor (A3AR) in the mouse heart. Their findings will feed further the current debate on the use of adenosine receptors (AR) as targets for gene therapy aimed at protecting the myocard...
متن کاملIvabradine in Cardiovascular Disease: Heart Rate Isn't Everything
The funny or hyperpolarization-activated cyclic nucleotide-gated channel (HCN) modulates cardiac excitability and heart rate by regulating the If or IKf current in sinoatrial cells. The 4 HCN channel isoforms (HCN1–4) are unique in that they are activated by both cyclic adenosine monophosphate (AMP) and hyperpolarized membrane channels. Thus, sympathetic activation of b-adrenergic receptors (b-...
متن کاملHeart-rate reduction by If-channel inhibition with ivabradine restores collateral artery growth in hypercholesterolemic atherosclerosis.
AIMS Collateral arteries protect tissue from ischaemia. Heart rate correlates with vascular events in patients with arterial obstructive disease. Here, we tested the effect of heart-rate reduction (HRR) on collateral artery growth. METHODS AND RESULTS The I(f)-channel inhibitor ivabradine reduced heart rate by 11% in wild-type and 15% in apolipoprotein E (ApoE)(-/-) mice and restored endothel...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 2015
ISSN: 0007-1188
DOI: 10.1111/bph.13220